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尿路代谢物是否反映了职业接触有机酸盐阻燃剂的情况? 一个电子废物回收工人的案例研究

Sabrina Gravel¹, Inna Tata Traore², Miriam L Diamond³

¹Institut Robert-Sauvé en santé et en sécurité du travail, Montreal, Quebec H3A 3C2, Canada; Department of Occupational and Environmental Health, School of Public Health, Université de Montréal, Montreal, Quebec H3T 1A8, Canada; Centre de recherche en santé publique (CReSP), Université de Montréal and CIUSSS du Centre-Sud-de-l'Île-de-Montréal, Montreal, Quebec H3N 1X9, Canada.

Toxicology letters

|April 4, 2025

概括

电子废物回收工人面临着有机酸 (OPE) 的暴露. 某些OPE (如TCEP和TBOEP) 的空气度较高与尿样中的代谢物水平增加有关.

科学领域:

环境健康环境健康
职业健康职业健康职业健康
毒理学毒理学毒理学

背景情况:

有机酸 (OPEs) 在电子产品中普遍存在,并可能对健康造成风险.
电子废物 (电子废物) 回收工人可能会在职业上受到OPE的严重影响.
了解OPE在电子回收环境中的暴露对于工人的安全至关重要.

研究的目的:

调查加拿大电子回收工人尿液中空气中OPE度及其代谢物之间的关系.
在这个高风险群体中确定监测职业OPE暴露的潜在生物标志物.

主要方法:

收集了来自六个电子回收设施的85名工人的个人空气样本和轮班结束尿液样本.
分析了OPE的空气样本,包括TPhP,TCEP,TCPP,TDCPP和TBOEP.
使用线性和托比特回归模型来评估空气度和尿中代谢物之间的关联,控制尿流速.

主要成果:

在90%-100%的空气样本中检测到OPE,TPhP,TCEP,TBOEP和TDCPP的几何平均值在250到404 pmol/m3之间.
在32%至98%的样本中检测到尿中的代谢物.
空气中TCEP度的翻倍与其代谢物的42-107%的增加有关;TBOEP空气度的增加与其代谢物的77%的增加有关.

结论:

在电子回收设施中,空气中的OPE度很大.
像TCEP和TBOEP这样的特定OPE显示了工作场所空气水平和尿路代谢物度之间的明显联系.
需要对OPE毒动力学进行进一步的研究,以完善电子回收中职业暴露的生物监测策略.

关键词:

生物监测生物监测电子回收电子设备的回收职业暴露职业暴露有机酸盐 Ester 是一种有机酸盐.

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