长期COVID综合征患者的冠状动脉血管反应异常 - 一项使用氧化敏感心血管磁共振的病例对照研究
Lukas D Weberling1, Elizabeth Hillier2, Matthias G Friedrich3
1Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany.
长期COVID患者在呼吸练习期间表现出心率反应受损和心肌氧化储备,这表明内皮功能障碍. 这种非侵入性测试可能有助于客观化症状,并了解长期COVID的心血管影响.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 血管生物学 血管生物学
背景情况:
- 长期COVID综合征在感染后呈现出持续的心血管症状.
- 标准心血管磁共振 (CMR) 显示长期COVID中没有急性损伤.
- 内皮功能障碍是长期COVID病理生理学的可疑贡献者.
研究的目的:
- 为了评估长期COVID患者的内皮功能,使用氧化敏感的CMR.
- 在长期COVID中评估呼吸诱导的心肌氧化储备 (B-MORE).
- 为了确定氧化敏感的CMR是否可以在长期COVID中对心血管症状进行客观化.
主要方法:
- 未来的观察病例控制研究,比较长期COVID患者和健康对照.
- 参与者接受了标准的CMR和氧化敏感的CMR,并进行呼吸练习.
- 在高通风和呼吸暂停期间评估心率响应和B-MORE.
主要成果:
- 两组之间标准CMR或心脏生物标志物没有显著差异.
- 长期COVID患者在呼吸练习期间表现出心率增加和显著降低B-MORE.
- 在长期COVID患者中,索引左心室中风体积较低.
结论:
- 氧化敏感的CMR揭示了长期COVID患者的血液动力学和心肌氧化反应受损.
- 这种非侵入性测试可能有助于客观化长期的COVID症状.
- 研究结果支持内皮功能障碍在长期COVID中起着重要作用.
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