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鼻内NAP (达文尼提德):神经保护和昼夜节律性
Artur Galushkin1, Illana Gozes1
1Dr. Diana and Zelman Elton Laboratory for Molecular Neuroendocrinology, Department of Human Molecular Genetics and Biochemistry, Faculty of Medical & Health Sciences, Adams Super Center for Brain Studies and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel.
达文尼提德 (NAP) 是ADNP的一种,在脑疾病中显示出神经保护的潜力. 临床试验表明在改善认知功能和减缓疾病进展方面具有安全性和有效性.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 分子生物学分子生物学
背景情况:
- 活动依赖神经保护蛋白 (ADNP) 对大脑发育和功能至关重要.
- 缺少ADNP与神经发育和神经退行性疾病有关,包括阿尔茨海默氏症和病.
- 循环节律失调也与ADNP功能有关.
研究的目的:
- 审查NAP (davunetide) 的神经保护潜力,NAP (davunetide) 是一种来自ADNP的.
- 在神经发育和神经退行性疾病的临床前和临床模型中评估NAP的疗效.
- 探索NAP对涉及病和昼夜调节失调的疾病的治疗影响.
主要方法:
- 对评估认知表现和行为缺陷的临床前研究的审查.
- 对鼻内NAP (davunetide) 临床试验数据的分析,关于安全性,生物可用性和疗效.
- 对II-III期临床试验的检查结果显示了渐进的超核性麻.
主要成果:
- 临床前研究表明,NAP有助于改善认知功能和纠正行为缺陷.
- 临床研究证实了NAP (davunetide) 的安全性,生物利用性和潜在的认知益处.
- 纳普 (达文尼提德) 显著减缓了进展性上核麻的妇女的疾病进展.
结论:
- 纳普 (davunetide) 是神经发育和神经退行性疾病的可行的治疗选择.
- 该增强了微管稳定性,并预防病,解决关键的病理机制.
- NAP的发展是减少主义药物输送方法的典范,该方法针对关键的ADNP相关途径.
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