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中和I型干扰素的自身抗体仍然是接种疫苗的患者中严重的COVID-19肺炎的重要危险因素

Arnau Antolí¹, José Luis Gómez-Vázquez², Angels Sierra-Fortuny³

¹Internal Medicine Department, Hospital Universitari de Bellvitge. L'Hospitalet de Llobregat, Barcelona, Spain; Adult Primary Immunodeficiency Unit (UFIPA), Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain; Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Faculty of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain.

Clinical immunology (Orlando, Fla.)

|April 4, 2025

概括

针对I型干扰素的中和性自身抗体增加了接种疫苗的个体的COVID-19肺炎危险. 尽管接种了疫苗,但这些自身抗体预测了严重的疾病,突显了持续的脆弱性.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
传染性疾病传染性疾病

背景情况:

对I型干扰素的中和性自身抗体与未接种疫苗的个体的严重COVID-19有关.
这些自身抗体在突破性感染的接种疫苗的个体中的作用以前没有被评估.

研究的目的:

为了研究I型干扰素自身抗体对COVID-19肺炎疫苗接种患者疾病严重性的影响.

主要方法:

从接种疫苗的COVID-19肺炎患者收集的临床和实验室数据.
评估了阻断干扰素-α2和-ω的自身抗体.
评估了对SARS-CoV-2疫苗接种的幽默反应.

主要成果:

458名接种疫苗的患者尽管有足够的抗体反应,但患上了COVID-19肺炎.
中和干扰素的自身抗体在严重的肺炎病例中更为普遍 (8.8%),而不是较轻的形式 (3.6%).
这些自身抗体独立预测了严重的COVID-19肺炎 (OR 2.88).

结论:

接种疫苗可以显著降低COVID-19的严重程度.
具有I型干扰素自身抗体的个体,即使在接种疫苗后,仍然面临严重COVID-19的更高风险.

关键词:

自体抗体中和I型干扰素.突破性COVID-19肺炎的突破性发现在 COVID-19 疫情中,免疫缺陷是一种免疫缺陷.疫苗接种疫苗接种

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