相关实验视频
Updated: Aug 12, 2026
10:34
Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
Published on: April 23, 2017
6.9K
单细胞粘合性类脂质体用于利用单细胞向瘤组织导向
Chia-Yu Chang1, Shih-Hsun Huang1, Chong-Yan Chen2
1Graduate Institute of Biomedical Engineering, National Chung-Hsing University, Taichung, Taiwan.
概括
新的单细胞介导药物载体 (MMDCs) 利用单细胞来向患病的组织. 这种新的方法提高了癌症模型中的药物输送和治疗疗效.
科学领域:
- 生物医学工程 生物医学工程
- 药物输送系统 药物输送系统
- 纳米技术 纳米技术
背景情况:
- 目前的药物输送严重依赖于被动组织透,限制了疗效.
- 单细胞具有先天的化学作用性质,积极迁移到受病的部位.
- 需要一种新的载体系统来利用单细胞指向向性传递.
研究的目的:
- 开发和评估单细胞介导药物载体 (MMDCs) 以提高药物输送.
- 调查MMDCs利用单细胞化疗来向患病组织的能力.
- 在临床前癌症模型中评估MMDCs的治疗疗效.
主要方法:
- 单细胞粘合性类脂质体 (MMDCs) 的发展.
- 在生理流程下对单细胞 (THP-1细胞) 进行MMDC的评估.
- 使用3D微流体乳腺癌模型 (MDA-MB-231) 评估向特异性的评估.
- 在巨细胞化后的体外药物释放研究.
- 在异种移植小鼠模型中体内评估瘤向和疗效.
主要成果:
- 在生理流动下,MMDCs有效地在循环单细胞上车.
- 在3D癌症模型中,MMDCs在3D癌症模型中展示了特定的向和跨内皮细胞迁移.
- 在巨细胞对MMDCs的细胞化时观察到多克索鲁比的释放.
- MMDCs显示出高瘤向效率和改善了药物生物分布在体内.
- 封装剂的治疗疗效得到了提高.
结论:
- 单细胞介导药物载体 (MMDCs) 代表了针对药物输送的有希望的战略.
- 利用单细胞的指导能力显著改善了药物的生物分布到疾病部位.
- MMDCs增强了封装剂的治疗疗效,提供了一种新的癌症治疗方法.
相关概念视频
01:19Cadherins in Tissue Organization
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Cell Sorting During Development
Cell sorting plays an...
01:25Selectins
Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...