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Updated: May 16, 2025

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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尼塔衍生物在μ-阿片类受体中的假定结合模型

Joseph Clayton1, Lei Shi2, Michael J Robertson3

  • 1Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, MD, 20993, USA; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, 21201, USA.

Neuropharmacology
|April 4, 2025
PubMed
概括

计算模拟揭示了强大的合成阿片类药物尼塔如何与阿片受体 (μOR) 结合. 研究结果表明,尼塔有利于特定的结合模式,为其高强度提供了洞察力,并指导了未来的药物设计.

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