儿童时期的逆境和前额前带带皮层的皮质厚度之间的跨诊断关系
Jasper van Oort1, Indira Tendolkar2, Janna N Vrijsen3
1Department of Psychiatry, Radboud University Medical Center, Nijmegen, Netherlands; Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, Netherlands; Addiction Institute of Mount Sinai, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, USA.
Journal of affective disorders
|April 4, 2025
概括
童年逆境 (CA) 与较薄的大脑区域有关,特别是左侧正面前带皮层 (rACC),无论心理健康状况如何. 这种结构变化可能会加剧与压力相关的疾病的疾病结果.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 童年逆境 (CA) 是精神疾病的主要风险因素.
- CA对大脑形态的影响,特别是面额前环状皮质 (rACC),主要研究在抑郁和焦虑中.
- rACC在情感功能中起着至关重要的作用,对CA敏感.
研究的目的:
- 为了研究CA,精神病理学和大脑结构在各种精神疾病之间的关系.
- 专门研究CA对压力相关和神经发育障碍中的rACC的影响.
主要方法:
- 研究了227名患有与压力有关的和/或神经发育障碍的患者和95名健康对照.
- 专注于使用神经成像技术测量左和右rACC的厚度.
- 与存在CA和精神病理症状相关的rACC厚度.
主要成果:
- 在整体样本中,CA与左侧rACC厚度的减少有关,独立于精神病理.
- 与对照组相比,精神病患者表现出较薄的右侧rACC,特别是在与压力有关的疾病组.
- 左侧rACC厚度与社会焦虑相关,而右侧rACC厚度与与压力有关的核心症状和神经发育障碍相关.
结论:
- 在与压力相关的疾病中,CA诱导的左侧rACC变薄可能会加剧右侧rACC变化的影响.
- 在rACC中这种"双击"机制可能会导致AC后的疾病轨迹较差.
- 这些发现突显了rACC对早期生活压力的脆弱性及其对精神疾病的影响.
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