穆坦皮层多糖的抗炎症和肠道菌群调节能力及其与大豆蛋白质分离物的相互作用
Yuxin Wen1, Wenbing Yan1, Ming Liu2
1School of Food Science and Engineering, Guangdong Provincial Key Laboratory of Green Processing of Natural Products and Product Safety, Engineering Research Center of Starch and Plant Protein Deep Processing, Ministry of Education, South China University of Technology, Guangzhou 510640, Guangdong Province, China.
穆坦皮层多糖化物 (PMCW1) 调节肠道细菌并减少炎症. 它与大豆蛋白分离物的复合物在消化后保持这些益处,表明作为功能性食品成分的潜力.
科学领域:
- 食品科学 食品科学 食品科学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 植物多糖因其抗炎和肠道健康益处而受到探索.
- 食品矩阵相互作用对多糖活性的影响需要进一步研究.
研究的目的:
- 研究来自Moutan皮层的纯化异多聚糖化物 (PMCW1) 的抗炎和肠道微生物群调节作用.
- 在模拟食品系统中评估PMCW1-大豆蛋白分离复合物的稳定性和生物活性.
主要方法:
- PMCW的净化和结构分析1.1.
- 在体外评估PMCW1对肠道微生物群组成和巨细胞炎症标志物的影响.
- PMCW1-大豆蛋白分离复合物的形成和特征及其在模拟胃肠道消化后的稳定性/生物活性.
主要成果:
- PMCW1通过降低Firmicutes/Bacteroidetes比率并促进Prevotella,Bifidobacterium和Lactobacillus等有益细菌,增加短链脂肪酸 (SCFA) 来改变肠道微生物群.
- PMCW1通过降低 lipopolysaccharide 诱导的巨细胞中的氧化 (NO) 和促炎因素,表现出抗炎性质.
- PMCW1-大豆蛋白分离复合物表现出增强的稳定性和可溶性,在消化后保持抗炎活性.
结论:
- PMCW1具有显著的抗炎和肠道微生物群调节能力.
- 与大豆蛋白分离物的复合增强了食品系统中PMCW1的稳定性和功能.
- PMCW1是开发可能预防或减轻代谢疾病的食品的一个有希望的功能成分.
更多相关视频
08:58Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
09:04DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
Published on: February 27, 2014
相关概念视频
Drugs for Treatment of Ulcerative Colitis in IBD
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Drugs for Treatment of Constipation-Predominant IBS
