结肠直肠癌神经切除术后的瘤和功能结果:一个系统的审查
Nathalie Braeckman1,2, Eva Kerckhove1,2, Andreas Denys1,2
1Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent, Belgium.
概括
结直肠癌的乳房切除术提供了有限的死亡率和改善的疼痛控制,大多数患者恢复了独立行走的能力. 然而,功能性结果,如肠道和膀的控制可能会受到影响,影响生活质量.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 结肠直肠癌是全球癌症死亡的主要原因之一.
- 乳房切除术是一种针对晚期直肠癌的重大手术,可以显著影响患者的生活质量.
- 研究瘤和功能性结局的圣切除术对于患者管理至关重要.
研究的目的:
- 评估结直肠癌患者的分泌切除术后的瘤结果 (生存率).
- 评估功能性结果,包括疼痛,移动性和器官功能,神经切除术后.
- 为了确定影响结直肠癌神经切除术后结果的因素.
主要方法:
- 对报告结直肠癌的圣切除术的研究进行系统审查.
- 包含标准基于在多个数据库 (PubMed,Embase等) 中预定义的搜索策略. ) 的情况.
- 通过独立审查员使用GRADE和ROBINS-I工具评估研究质量.
主要成果:
- 分析了46篇关于1687名患者的文章;中位数随访时间为31.4个月.
- 经过R0切除,在1年实现了86.2%的整体存活率,在5年后降至42.1%.
- 大多数患者经历了疼痛减轻和恢复独立行走;然而,肠/膀功能障碍和高与低分泌切除术的影响被注意到.
结论:
- 结直肠癌的乳房切除术表明30天死亡率有限 (1.1%) 和可接受的发病率.
- 与R1/R2切除相比,R0切除与显著更高的生存率有关.
- 虽然R0切除的瘤结果很有希望,但功能性缺陷会影响生活质量,需要进一步调查.
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