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Updated: May 16, 2025

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生物打印和合成生物学方法设计功能性内分泌胰腺结构

Davide Ribezzi1, Pere Català1, Cataldo Pignatelli2

  • 1Department of Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Trends in biotechnology
|April 4, 2025
PubMed
概括

研究人员正在生物打印功能性内分泌胰腺以治疗糖尿病. 这种再生方法旨在创建可移植的移植物,以实现胰岛素独立.

关键词:
生物打印是一种生物打印技术.在糖尿病中,糖尿病是血糖性糖尿病.内分泌 胰腺 胰腺多能干细胞是一种多能干细胞.合成生物学 合成生物学组织工程是组织工程.

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Insulin: Biosynthesis, Chemistry, and Preparation01:25

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The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
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