PsycGM:一个全面的数据库,用于肠道微生物群和精神疾病之间的关联
Dongfang Wang1,2,3, Siwen Gui1,2,3, Juncai Pu1
1Department of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Molecular psychiatry
|April 4, 2025
概括
一个新的数据库,PsycGM,整合了精神疾病的肠道微生物组数据. 它揭示了抑郁症中的关键微生物关联,为新的治疗点提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 基因组学就是基因组学.
背景情况:
- 精神疾病对全球健康构成重大挑战,治疗选择有限.
- 人们越来越认识到肠道微生物在通过肠-大脑轴调节中对中枢神经系统的作用.
- 现有的精神疾病的元基因组学数据是分散在不同的研究和物种.
研究的目的:
- 创建一个全面的,精心策划的数据库 (PsycGM) 的肠道微生物群与精神疾病的关联.
- 整合各种表型,干预和物种的高通量数据.
- 提供一个有价值的资源,用于调查在心理健康的肠道失调.
主要方法:
- 手动策划和注释数据库开发.手动策划和注释数据库开发.
- 整合了来自31个国家的559项研究,包括人类和动物模型.
- 系统地记录微生物种类,精神疾病和干预措施之间的关联.
主要成果:
- PsycGM包括1514种微生物种群和11种精神疾病之间的8907个关联.
- 它还记录了869个类型和232个干预之间的4050个关联.
- 分析揭示了在抑郁症中持续改变的特定微生物种群,例如人类的Parabacteroides和Alistipes,以及动物模型中的Helicobacter和Lactobacillus.
结论:
- PsycGM是了解肠道微生物群在心理健康中的作用的全面资源.
- 该数据库有助于对肠道疾病的研究,并有助于识别新的治疗点.
- 它可以探索基于微生物群的精神疾病干预措施.
相关概念视频
Irritable Bowel Syndrome I: Introduction
210
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
210
Anatomy of the Intestines
70.8K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
70.8K
Biological Causes of Schizophrenia
29
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
29
Chronic Bowel Disorders: Introduction
345
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
345
What is Monogastric Digestion?
69.9K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
69.9K
Bulimia Nervosa
41
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
41


