提醒疫苗接种增加了可检测的B细胞反应在多发性硬化症患者治疗ocrelizumab的人
Lucia Moiola1, Alessandra Mandelli2, Maciej Tarkowski3
1Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Journal of neurology
|April 4, 2025
概括
重复的COVID-19 mRNA疫苗接种促进了多发性硬化症患者 (pwMS) 接受ocrelizumab治疗的T细胞和B细胞反应. 免疫反应性随着时间的推移而持续,尽管它可能在接种疫苗后大约两年内下降.
科学领域:
- 免疫学 免疫学 免疫学
- 神经学 神经学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 在接受ocrelizumab治疗的多发性硬化症患者 (pwMS) 中,重复接种SARS-CoV-2疫苗的疗效仍然不确定.
- 奥克雷利祖马布是一种免疫抑制疗法,可以影响疫苗反应.
研究的目的:
- 评估用ocrelizumab治疗的pwMS患者对mRNA SARS-CoV-2疫苗接种的抗体和T细胞免疫反应.
- 评估重复疫苗接种周期对免疫细胞反应性的影响.
主要方法:
- 使用ELISPOT测定用于IFN-γ检测和多参数流细胞计来评估T细胞激活的外周血液单核细胞 (PBMC) 的分析.
- 使用商业平台量化血中的抗SARS-CoV-2尖峰和核囊抗体.
主要成果:
- mRNA COVID-19 疫苗接种引发了针对 SARS-CoV-2 尖端蛋白的强大和持续的 T 细胞反应,在重复的疫苗接种周期中持续存在.
- 流细胞计证实了接种疫苗后CD8+ T记忆干细胞的存在和增加,反映了抗体水平的变化.
- 免疫反应在最后一次接种疫苗后大约两年出现下降的趋势.
结论:
- 重复接种疫苗周期显著提高T细胞和B细胞针对SARS-CoV-2的免疫反应性. 在治疗了ocrelizumab的pWMS中.
- 这些发现支持在这种患者群体中持续接种疫苗的有效性.
更多相关视频
09:41Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography
Published on: January 20, 2023
1.7K
10:11Expression of Exogenous Antigens in the Mycobacterium bovis BCG Vaccine via Non-genetic Surface Decoration with the Avidin-biotin System
Published on: January 31, 2018
9.3K
相关概念视频
Immunological Memory
490
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
490
Vaccinations
43.1K
Overview
43.1K
Cross-reactivity
30.9K
Overview
30.9K
Cells of the Adaptive Immune Response
716
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
716
B Cell Activation and Differentiation
1.3K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.3K
