与口腔癌相关的微生物和代谢物的潜在变化:一项初步研究
Kaitong Wei1, Yaqing Ma1, Jing Xu1
1Oral and Maxillofacial Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, 450052, China.
BMC cancer
|April 4, 2025
概括
口腔癌会改变口腔微生物组和代谢物概况. 关键的发现包括特定细菌和因多尔相关代谢物的变化,为口腔状细胞癌提供了新的诊断和治疗途径.
科学领域:
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 在瘤学瘤学.
背景情况:
- 口腔状细胞癌 (OSCC) 是一个重要的全球健康问题,死亡率高.
- 口腔微生物群的变化越来越多地被认为在OSCC发育中起作用.
- 了解这些微生物和代谢变化对于OSCC的诊断和治疗至关重要.
研究的目的:
- 研究与健康个体相比,OSCC患者的口腔微生物和代谢物特征.
- 识别与口腔癌相关的特定细菌种群和代谢物.
- 探索口腔微生物组组成和OSCC中的代谢变化之间的相关性.
主要方法:
- 从40名OSCC患者和39名健康对照人群收集了唾液样本.
- 使用16S rDNA基因测序进行了口腔微生物组分析.
- 使用 Metorigin 平台使用液态染色学质谱法 (LC-MS) 进行了代谢组概况.
- 斯皮尔曼相关性被用来分析微生物组-代谢组关系.
主要成果:
- 在OSCC患者和对照人群之间观察到口腔微生物群的β多样性的显著差异.
- 在OSCC中,特定的细菌类 (Deferribacterota增加,菌减少) 和属 (Vibrio,乳球菌增加;Bifidobacterium, Faecalibacterium减少) 发生了变化.
- 代谢分析显示了36种代谢物的显著变化,包括对13(S) -HOTrE,13-HODE和与醇相关的化合物的下调,以及对多可萨纳米德的上调.
- N-乙神经氨基酸与Pseudoalteromonas和Vibrio.com有显著的负相关性.
结论:
- 口腔微生物组合和代谢物水平的显著差异,特别是与印相关的化合物,与OSCC有关.
- 这些发现凸显了口腔微生物组和代谢组分析在OSCC诊断方面的潜力.
- 鉴定的微生物和代谢特征为针对口腔状细胞癌的新疗法提供了有希望的方向.
相关概念视频
01:25Mutagenicity and Carcinogenicity
1.2K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.2K
02:53Adaptive Mechanisms in Cancer Cells
5.6K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.6K
02:59Cancer Prevention
6.0K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.0K
02:17The Tumor Microenvironment
6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K
02:07Tumor Progression
6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K
02:49Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K