重复的腰椎穿刺后的反应性多细胞瘤 - - 对临床实践的影响
Martin Schmidauer1, Fabian Föttinger2,3, Klaus Berek1
1Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
European journal of neurology
|April 5, 2025
概括
在大约三分之一的患者中,重复的腰部穿刺 (LP) 可以引起轻度反应性细胞瘤,特别是当在10天内进行时. 这一发现对于解释多次LP后脑脊液 (CSF) 结果很重要.
科学领域:
- 神经学 神经学
- 临床诊断 临床诊断 临床诊断
- 大脑脊髓液分析
背景情况:
- 腰部穿刺 (LP) 是一种常见的程序,有时需要重复.
- 重复LP对脑脊液 (CSF) 的影响尚不清楚.
研究的目的:
- 评估重复的LP是否会导致反应性多细胞化或血液-中枢神经液屏障问题.
- 为了评估重复LP之间的间隔的影响.
主要方法:
- 包括患有非炎症性神经疾病的患者和至少两名LP.
- 分析了基于LP间隔的CSF白细胞计数 (WBC),总蛋白质 (TP) 和白蛋白系数 (Qalb) 的纵向变化.
主要成果:
- 在27%的患者中,在重复LP后发生了多细胞瘤 (增加WBC).
- 当第二次LP发生在10天内 (3.5天而不是7天) 时,细胞瘤更常见.
- 脑液中总蛋白质和白蛋白系数在患有多细胞瘤的患者中略有增加.
结论:
- 轻度反应性细胞症可能发生在大约三分之一的患者中,这些患者经历了重复的LP.
- 重复LP的时间,特别是在10天内,与反应性多细胞症有关.
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