评估血清S-Equol,硫酸和TMAO用于预测儿童尿路结石:一项前性研究
Aylin Gencler1, Hakim Celik2, Abit Demir3
1Department of Pediatric Nephrology, Harran University Faculty of Medicine, Şanlıurfa, Turkey. aylinsam@gmail.com.
Urolithiasis
|April 5, 2025
概括
患有尿路结石的儿童的S-equol和三甲基胺N-氧化物 (TMAO) 含量较低,这些代谢物与肠道细菌有关. 这些发现表明,这些肠道微生物群相关代谢物和儿科尿路结石的发展之间存在潜在的联系.
科学领域:
- 微生物学 微生物学
- 儿科脏病学 儿科脏病学
- 代谢学 代谢学 代谢学
背景情况:
- 肠道微生物群在整体健康中起着至关重要的作用,并且越来越多地被认为与尿路结石疾病有关.
- 在有或没有尿路结石的个体中观察到不同的微生物组成.
研究的目的:
- 在患有尿路结石疾病的儿童中检查血清中S-equol,硫酸 (IS) 和三甲基胺N-氧化物 (TMAO) 的水平.
- 评估这些肠道微生物群相关代谢物的预后价值,以预测儿科患者的结石形成.
主要方法:
- 一项病例控制研究涉及44名患有尿路结石疾病的儿童和44名年龄和性别匹配的健康对照.
- 血清中S-equol,氧硫酸 (IS) 和三甲基胺N-氧化物 (TMAO) 的水平被测量并在两组之间进行比较.
- 在代谢物水平和年龄之间进行了相关性分析.
主要成果:
- 与健康对照人群相比,患有尿路结石疾病的儿童的血清S-equol和TMAO水平明显较低.
- 两组之间血清氧硫酸盐 (IS) 含量没有显著差异.
- 在这两组人群中,血清代谢物水平与年龄之间没有明显的相关性.
结论:
- 患有尿路结石疾病的儿童的血清S-equol和TMAO水平显著降低.
- 这些发现表明,这些肠道微生物群衍生代谢物的较低水平与儿童尿路结石病变之间的潜在关联.
相关概念视频
Urinary Tract Calculi I: Introduction
1.1K
Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
1.1K
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
863
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
863
Urinary Tract Calculi III: Medical Management
402
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
402
Urinary Tract Calculi IV: Nutrition Therapy and Prevention
764
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
764
Urinary Tract Calculi V: Nursing Management
496
AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
496
Urinary Tract Calculi VI: Surgical Management
1.0K
Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
1.0K


