父母在分娩前吸烟和孩子患上多发性硬化症:一项病例对照研究
Sanaz Khodadadi1,2, Sahar Nikkhah Bahrami1,2, Shima Jahani1
1Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Acta neurologica Belgica
|April 5, 2025
概括
在怀孕前和怀孕期间,父亲吸烟显著增加了后代患多发性硬化症 (MS) 的风险. 对于预防多发性硬化而言,公众对这种可预防的危险因素的认识至关重要.
科学领域:
- 神经学 神经学
- 环境健康 环境健康
- 遗传学 遗传学 是一个
背景情况:
- 多发性硬化症 (MS) 的发病因子受到遗传和环境因素的影响.
- 产前和产周环境暴露可能会影响MS的发病和进展.
- 关于父母吸烟对MS发展的影响的研究是有限的.
研究的目的:
- 调查父母在分娩前吸烟与后代多发性硬化症风险之间的联系.
- 为了确定MS发展的潜在环境风险因素.
主要方法:
- 一项病例控制研究与379名多发性硬化患者和379名对照进行.
- 用问卷收集了有关父母吸烟习惯,性别和年龄的数据.
- 采用二进制逻辑回归来分析父母吸烟与MS发病之间的关联,并对混因素进行调整.
主要成果:
- 怀孕前父亲每日吸烟与后代患MS风险增加65%有关 (AOR=1.65).
- 怀孕期间父亲每天吸烟与后代患MS的风险增加71%有关 (AOR=1.71).
- 在怀孕前或怀孕期间,母亲吸烟与后代MS发病没有显著的关联.
结论:
- 在怀孕前和怀孕期间,父亲吸烟是后代患MS的重要危险因素.
- 这些发现强调了公共卫生倡议的重要性,并进一步研究了父亲吸烟作为MS可修改的风险因素.
- 提高人们对父亲吸烟对后代多发性硬化风险的影响的认识,对于预防策略至关重要.
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