口腔微生物和胃肠道癌症:新的策略和见解
Chenlu Huang1,2, Yu Li1,2, Cong He3
1Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang, 330006, Jiangxi Province, China.
概括
通常在肠道微生物群中发现的口腔微生物与胃肠道 (GI) 癌症有关. 本综述探讨了这些微生物如何影响癌症的发展,并强调了免疫调节作为一个关键机制.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 胃肠道 (GI) 癌症是全球主要的健康问题,肠道微生物群失生症与其发展有关.
- 新兴研究强调了口腔微生物在胃肠道癌症,特别是结肠直肠癌中的重要作用.
研究的目的:
- 审查口腔微生物多样性和丰富性在食道,胃和结肠直肠癌的变化.
- 探索口腔微生物影响肠胃癌的机制,包括免疫调节,表观遗传学和亡.
主要方法:
- 在体内和体外研究的文献综述.
- 对研究肠道癌症口腔微生物相互作用的分子技术的分析.
主要成果:
- 口腔微生物通过唾液被运送到肠道,影响肠道健康和癌症进展.
- 关键机制包括免疫调节,表观遗传学和亡,免疫调节与癌症治疗有着密切的联系.
结论:
- 口腔微生物失生症是胃肠道癌症发展的关键因素.
- 需要进一步的研究来充分了解这些机制及其治疗潜力,特别是专注于免疫调节.
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