根据动脉样硬化血管疾病的严重程度,高灵敏度热素的预后效用

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Julia Rohde¹, Fabian J Brunner², Alina Goßling³

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概括

高灵敏度的热素T和I (hsTnT/I) 预测了动脉样性血管疾病 (ASVD),特别是多血管疾病 (PolyVD) 患者的全因死亡率. 这些生物标志物对ASVD患者的风险分层有价值.

科学领域:

心脏病学心脏病学
生物标志物生物标志物
血管疾病血管疾病

背景情况:

多血管疾病 (PolyVD),定义为多个血管床的动脉样性血管疾病 (ASVD),具有高风险的不良结果.
在多重疾病患者中,高灵敏性托罗T和I (hsTnT/I) 的预后价值仍未得到充分研究.

研究的目的:

调查hsTnT/I水平与ASVD程度之间的关联.
探索hsTnT/I在预测ASVD患者临床结果中的预后效用.

主要方法:

从INTERCATH队列研究中对2273名接受冠状动脉血管造影的患者的hsTnT/I度进行分析.
分为分组的分层:没有ASVD,单血管疾病 (MVD) 和多血管疾病.
考克斯回归分析以评估hsTnT/I,ASVD程度和结果 (全因死亡率,主要心血管不良事件[MACE]) 之间的关系.

主要成果:

观察到hsTnT和hsTnI的逐步增加,随着ASVD程度的增加,尽管经过调整后在统计学上并不显著.
hsTnT和hsTnI独立地与多种疾病和MVD患者的全因死亡率相关.
在ASVD负担的全谱中,hsTn水平和MACE之间没有发现显著的关联.

结论:

较高的hsTnT/I度与ASVD的更大程度以及所有原因死亡率和MACE的发病率增加相关.
hsTnT/I水平可靠地与ASVD患者的全因死亡率有关.
像hsTnT/I这样的生物标志物在提高动脉样硬化血管疾病患者的风险预测方面发挥着至关重要的作用.

关键词:

所有原因的死亡率.高灵敏度的托罗邦尼.主要的不良心血管事件.多血管疾病是多血管疾病.风险预测风险预测

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