在6名儿童中轻度头部/轨道创伤后的MOGAD视神经炎
Alexander J Sandweiss1, Jonathan Rosen1, Chaitanya Aduru1
1Department of Pediatrics, Section of Neurology and Developmental Neuroscience, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, United States of America.
Journal of neuroimmunology
|April 5, 2025
概括
轻微的头部创伤可能会触发髓类寡腺细胞糖蛋白抗体相关疾病 (MOGAD),在年轻患者中呈视神经炎 (ON). 这表明MOGAD-ON.的潜在非传染性触发因素.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 眼科医生 眼科 眼科
背景情况:
- 髓寡腺细胞糖蛋白抗体相关疾病 (MOGAD) 是一种可以导致视神经炎 (ON) 的脱髓化疾病.
- 确切的触发因素和MOGAD的潜在原因尚未完全理解.
- 头部创伤通常不被认为是MOGAD的直接触发因素.
研究的目的:
- 为了调查轻度头部/轨道创伤与MOGAD-ON在年轻患者的发病之间的潜在联系.
- 描述了在头部创伤后对MOGAD-ON的一项新的临床观察.
主要方法:
- 一个单一中心的回顾性病例系列比较了六名年轻患者,在头部创伤后接受了MOGAD-ON,与与孤立的MOGAD-ON相匹配的年龄对照进行了比较.
- 数据收集包括患者人口统计,创伤史,临床表现,MOGAD诊断,治疗和结果.
主要成果:
- 六名患者 (8-18岁) 在轻度头部创伤后大约5.5天内发生了ON,所有这些患者的抗转基因抗体检测呈阳性.
- 四名患者在单边创伤后出现单边ON;两名患者在中线创伤后出现双边ON.
- 所有患者对静脉输入的皮质类固醇反应迅速,在5.5周内完全恢复视力,没有复发.
结论:
- 轻微的头部创伤可能会在敏感个体中起到MOGAD-ON的诱导作用.
- 这一发现表明MOGAD-ON的潜在非传染病理生理机制.
- 需要进一步的研究,以确定头部创伤是否会使个体倾向于MOGAD-ON.
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