双相情感障碍中精神病的临床高风险:临床特征,认知和功能
Simge Uzman Ozbek1, Burcu Verim2, Aybüke Kucukakdag2
1Kastamonu Education and Research Hospital, Kastamonu, Turkey.
Psychiatry research
|April 5, 2025
概括
双极性障碍和临床高危精神病 (BD-CHR-P) 患者表现出更严重的症状,包括精神病特征和思维障碍. 与其他双相情感障碍患者相比,这个小组也表现出明显较差的功能和较高的冲动性和冷漠度.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 神经科学是一个神经科学.
背景情况:
- 双极性障碍 (BD) 是一种复杂的心理健康状况,表现各异.
- 识别BD中的子组对于理解疾病异质性和改善治疗至关重要.
- 与精神分裂症的重叠需要调查BD在euthymic状态期间的精神病风险.
研究的目的:
- 定义和调查双极性障碍的一个子组与临床高风险的精神病 (BD-CHR-P).
- 为了比较神经认知,社会认知,功能,思维障碍和BD-CHR-P和没有这种综合症的BD之间的临床特征.
- 确定BD中精神病发展的潜在临床标志物.
主要方法:
- 采用了生长综合征结构面试 (SIPS) 来识别BD-CHR-P亚组.
- 包括77名参与者,其中25名被归类为BD-CHR-P.
- 在不同组之间比较临床特征,认知,功能,思维障碍,冷漠,冲动和精神分裂.
主要成果:
- 在BD-CHR-P组,在躁狂发作期间,精神病特征和施奈德尔症状的发病率较高.
- 在BD-CHR-P组观察到心理社会功能较差 (p < 0.001).
- 在BD-CHR-P组中,预期性无情,正面的形式思维障碍,冲动性,冷漠和精神分裂症的得分较高.
结论:
- 该BD-CHR-P亚组呈现出明显的临床和功能障碍.
- 这些发现表明BD-CHR-P可能代表双相情感障碍中具有临床意义的表型.
- 需要进一步的研究,以了解这些特征的潜在机制和预测价值,以预测未来的精神病障碍.
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