阻力训练诱导的二丸在老老鼠的骨肌肉中变得
Yung-Li Hung1, Akihito Ishigami2, Shuichi Machida3
1Japan Society for the Promotion of Science, 5-3-1 Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan; Graduate School of Health and Sports Science, Juntendo University, 1-1 Hirakagakuendai, Inzai, Chiba 270-1695, Japan.
The journal of physiological sciences : JPS
|April 5, 2025
概括
衰老会损害抵抗训练在肌肉类固醇激素生产中的收益. 抵抗运动在年轻的老鼠中增加了二丸激素,但这种效果在老老鼠中消失了,这表明随着年龄的增长,荷尔蒙反应会减弱.
科学领域:
- 内分泌学 在内分泌学.
- 运动生理学 运动生理学
- 骨肌肉生物学 骨肌肉生物学
背景情况:
- 衰老与肌肉损失和减少身体功能有关.
- 类固醇激素在肌肉适应运动方面发挥作用.
- 衰老对肌肉中运动诱导的类固醇激素产生的影响尚不清楚.
研究的目的:
- 调查衰老对抗力训练后骨肌肉中类固醇激素产生的影响.
- 为了比较年轻与老老鼠对抵抗训练的肌肉反应.
主要方法:
- 雄性F344大鼠 (年轻:4个月;年长:22个月) 接受了为期8周的抵抗训练计划 (随负荷爬梯子).
- 肌肉组织 (flexor hallucis longus) 用液体色谱-并联质谱分析了类固醇激素水平.
- 在训练后测量肌肉质量.
主要成果:
- 抵抗训练在年轻和老老老鼠中增加了肌肉质量,在年轻老鼠中观察到的增加更大.
- 肌肉二二的水平显著增加 (35倍) 在年轻的,训练有素的老鼠与静止控制相比.
- 与久坐不动的老鼠相比,在老,训练有素的老鼠中,二二的水平没有显著变化.
结论:
- 抵抗训练刺激了年轻大鼠骨肌肉中的二托的产生.
- 衰老显著削弱了肌肉增加二激素生产的能力,以应对抵抗训练.
- 这些发现凸显了骨肌肉对运动的内分泌反应中与年龄相关的变化.
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