血tRNA衍生小RNA调解了中国成年人从病例对照研究中发现的佐[a]烯暴露与肺癌风险之间的关联
Yang Xiao1, Chenliang Liu1, Xin Guan1
1Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Ecotoxicology and environmental safety
|April 5, 2025
概括
这项研究揭示了血tRNA衍生小RNAs (tsRNAs) 可能会调解与[a]pyrene (BaP) 暴露相关的肺癌发展. 这些tsRNAs显示为BaP诱导的肺癌的生物标志物的潜力.
科学领域:
- 环境表观遗传学环境表观遗传学
- 分子瘤学分子瘤学
- 生物标志物发现发现
背景情况:
- [a]烯 (BaP) 暴露与肺癌有关,但机制尚不清楚.
- 血tRNA衍生小RNAs (tsRNAs) 是新兴的表观遗传生物标志物.
- tsRNAs可能会弥合环境暴露和肺癌的发展.
研究的目的:
- 为了识别与肺癌风险相关的血tsRNA特征.
- 为了研究tsRNAs在BaP诱导的肺癌中介作用.
- 探索tsRNAs作为BaP相关的肺癌的潜在生物标志物.
主要方法:
- 对272名参与者的病例控制研究.
- 血tsRNA测序和检测本佐[a]皮烯二醇环氧化-蛋白 (BPDE-Alb) 添加物.
- 线性回归和调解分析以评估tsRNA与肺癌和BaP暴露的关联.
主要成果:
- 确定了104个与肺癌风险有显著关联的tsRNAs.
- 在手术前和手术后发现了17个具有差异表达的tsRNA.
- 观察到特定的tsRNAs (5'-M-tRNA-Glu-CTC-1-1-L36,i-M-tRNA-Met-CAT-1-1-L24_pos29,i-M-tRNA-Ala-AGC-2-2-L16_pos16) 调解了36.8%-40.8%的BaP与肺癌的关联.
结论:
- 血tsRNAs涉及到调解BaP诱导的肺癌.
- 特定的tsRNAs显示为BaP相关的肺癌的生物标志物.
- 这项研究强调了tsRNAs在环境致癌和癌症检测中的作用.
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