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来自内植物Neohendersonia kickxiixii的氧双衍生物

Reo Takahashi¹, Zulfikar¹, Mayuka Hakozaki²

¹Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan.

|April 5, 2025

概括

从内生植物Neohendersonia kickxii RT-749.9中分离出了三种新的新二醇 (1-3). 这些化合物对人类前兆细胞白血病 (HL60) 细胞和抗菌活性具有显著的细胞毒性.

科学领域:

自然产品化学自然产品化学
微生物学微生物学
药理学药理学是指药理学的学科.

背景情况:

内生菌是新型生物活性化合物的丰富来源.
尼奥亨德索尼亚基克西 RT-749是一种内生菌,具有产生独特代谢物的潜力.

研究的目的:

从内生菌菌Neohendersonia kickxii RT-749.xii中分离和描述新型化合物.
评估分离化合物的细胞毒性和抗菌活性.

主要方法:

使用色谱技术分离化合物.
通过包括NMR,UV,IR,HRESITOFMS和ECD在内的全面光谱分析来阐明结构.
细胞毒性测定对人类前细胞性白血病 (HL60) 细胞.
抗菌活性测定对抗细菌细菌.

主要成果:

鉴定出了三种新的氧双化合物,即新双A (1),B (2) 和C (3).
已知的二乙烯 (4,5) 和二福兰 (6) 也被分离出来.
化合物1-3显示出对HL60细胞的细胞毒性,其IC50值在3.7至7.3μM之间.
化合物1-3表现出抗菌活性对细菌细菌,MIC为25μg/mL.

结论:

新亨德索尼亚基基xii RT-749产生具有显著生物活性的新型氧双化合物.
隔离的化合物,特别是neohenbiphenylols A-C,显示出作为潜在的细胞毒性和抗菌剂的希望.

关键词:

抗微生物药物是一种抗菌药物.细胞毒性细胞毒性尼奥亨德森尼亚球xiixii 醇二聚物是二聚物中的一种.氧双烯 (Phenoxybiphenyl) 是一种一种

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