在怀孕期间通过in silico分析识别内分泌干扰化学物质,以准NTD相关的枢纽基因
Junjie Guo1, Hao Yu1, Yujun Guo1
1Department of Pediatric Surgery, The Sixth Affiliated Hospital of Harbin Medical University, Harbin Medical University, No. 998 Aiying Street, Harbin, Heilongjiang 150023, China.
Reproductive toxicology (Elmsford, N.Y.)
|April 5, 2025
概括
这项研究确定了与神经管缺陷 (NTD) 相关的关键基因,并揭示了72种针对它们的内分泌破坏性化学物质 (EDC),包括阿特拉辛和BPA,为NTDs的环境原因提供了新的见解.
科学领域:
- 环境健康 环境健康
- 发展生物学 发展生物学
- 毒理学 毒理学 毒理学
背景情况:
- 神经管缺陷 (NTD) 是一种严重的先天性形,具有复杂的基因环境相互作用.
- 内分泌干扰化学物质 (EDC) 是环境污染物,对人类健康构成风险,特别是在怀孕期间.
- 由于胎盘转移,孕妇容易受到EDC的影响,影响胎儿发育.
研究的目的:
- 使用胎盘和胎儿转录组数据识别与NTD相关的枢纽基因.
- 预测和验证针对这些已识别的枢纽基因的EDC.
- 阐明特定EDC在怀孕期间NTD发展中的作用.
主要方法:
- 对胎盘和胎儿转录组数据的分析,以确定与NTD相关的枢纽基因.
- 利用比较毒基因组学数据库 (CTD) 预测EDC针对枢纽基因.
- 进行了分子对接,以评估EDC与标蛋白之间的结合亲和力.
主要成果:
- 确定了四个与NTD显著相关的枢纽基因 (CTSC,FCER1G,ITGB2,LYVE1).
- 发现了72个EDC,这些EDC的目标是这些已识别的枢纽基因.
- 分子对接证实了阿特拉辛,双A (BPA) 和二之间与核心基因编码的蛋白质之间的稳定相互作用.
结论:
- 环境EDCs,包括atrazine,BPA和diuron,都与NTDs的病因有关.
- 这项研究为将EDC暴露与NTD发展联系起来的分子机制提供了新的见解.
- 研究结果强调需要进一步研究EDC缓解策略,以防止NTDs.
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