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碳酸空心微球封装纤维素纳米纤维/藻酸盐水凝作为一个连续的输送系统
Wenqian Bai1, Haiying Chen2, Junyao Li1
1Jiangsu Key Laboratory of Advanced Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China.
International journal of biological macromolecules
|April 5, 2025
概括
这项研究提出了一种用于结直肠癌的顺序药物递送系统. 它释放易布洛芬来缓解肠道的疼痛,以及多克索鲁比来治疗结肠癌.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 结肠直肠癌 (CRC) 治疗通常涉及化疗,这可能会引起严重的疼痛.
- 有效的向药物输送到结肠仍然是一个挑战.
- 开发用于同时治疗疼痛和治疗癌症的系统是非常可取的.
研究的目的:
- 开发一种新的顺序药物递送系统 (SDS),用于向释放化疗和止痛药物.
- 使用叶酸模板碳酸空心微球 (CaCO3 HMs) 进行多克索鲁比辛化 (DOX) 装载.
- 在纤维素纳米纤维/藻酸盐水凝中与布洛芬 (IBU) 共同封装DOX载 CaCO3 HM,以便连续释放.
主要方法:
- 使用叶酸作为模板通过奥斯瓦尔德成熟制备CaCO3 HM.
- 将DOX加载到CaCO3 HM,并将IBU加载到CNF/SA水凝中.
- 在水凝矩阵内同时封装载有DOX的CaCO3 HM和IBU.
- 在模拟肠道 (pH 7.4) 和结肠 (pH 6.5) 条件下的体外释放研究.
- 对药物释放动态的分析.
主要成果:
- 实现了高负载效率:95.7%的DOX在CaCO3HM中,97.0%的IBU在水凝中.
- 观察到的顺序释放:IBU在肠道中释放 (57.8%在pH7.4),随后在结肠中释放DOX (50.1%在pH6.5).
- IBU释放遵循第一阶段动力学,而DOX释放遵循零阶段动力学.
- 该SDS有效地将DOX输送到结肠,并同时提供疼痛缓解.
结论:
- 开发的SDS使得可针对性地将多克索鲁比辛输送到结肠以治疗结肠直肠癌.
- 该系统通过在肠道中释放布洛芬,同时提供疼痛缓解.
- 这种双重作用的输送系统有望提高化学疗法疗效和CRC治疗期间的患者舒适度.
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