鱼类中的抗生素红色素:药理动力学,作用和健康风险
Yongqi Tong1, Jiahua Guo2, Feilong Li3
1Guangdong Provincial Key Laboratory of Marine Disaster Prediction and Prevention, Shantou University, Shantou, 515063, China.
Environmental pollution (Barking, Essex : 1987)
|April 5, 2025
概括
红素是一种用于兽医的抗生素,污染了水生环境,伤害了鱼类. 这份审查详细介绍了其对环境的影响,药理动力学和鱼类的毒性,强调了对水生生态系统和人类消费者的风险.
科学领域:
- 环境科学 环境科学
- 水生毒理学 水生毒理学
- 兽医药理学 兽医药理学
背景情况:
- 红素是一种广泛用于兽医和水产养殖的宏类抗生素.
- 由于广泛使用,其在水生系统中的存在正在增加,这引发了对抗性和生态影响的担忧.
- 鱼类是受到红素影响的关键水生生物,生物积累和毒性数据需要合成.
研究的目的:
- 提供关于红色素对鱼类的环境命运,检测,药理动力学和毒理影响的全面概述.
- 综合现有关于红色素对鱼类健康影响的数据.
- 评估红色素对鱼类和潜在的人类消费者构成的环境健康风险.
主要方法:
- 文献综述和数据对红素在环境中的发生情况进行对比.
- 对水生环境中的红红素检测方法研究的分析.
- 汇编了关于红红素在鱼类中的药理动力学和毒理作用的研究,包括细胞毒性,器官毒性,神经毒性,发育毒性和生殖毒性.
主要成果:
- 在度从μg/L到mg/L的鱼类中,暴露于红素会破坏防御,抗氧化和代谢系统.
- 观察到的影响包括氧化应激,细胞损伤和代谢障碍.
- 毒性表现为细胞毒性,器官损伤,神经毒性,发育问题和生殖问题.
结论:
- 红素通过各种毒理途径对鱼类健康构成重大风险.
- 需要进一步研究高剂量对抗耐药病原体的疗效以及在环境相关度下长期影响.
- 对于鱼类和人类消费者来说,由于红红污染,进行彻底的风险评估至关重要.
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