长化合物通过调节肠道益生菌和病原细菌平衡来缓解Eimeria tenella感染症状
Jiajia Yang1, Xuan Wang2, Ying Chen1
1College of Animal Science, Guizhou University, Guiyang, Guizhou Province 550025, PR China; Key Laboratory of Animal Diseases and Veterinary Public Health of Guizhou Province (Cultivation), Guiyang, Guizhou Province 550025, PR China.
Veterinary journal (London, England : 1997)
|April 5, 2025
概括
长青化合物有效地预防了的状菌病,改善了存活率和免疫反应. 这种传统的中医药通过促进有益的细菌和减少病原体来增强肠道健康,为禽类疾病控制提供了一种新的方法.
科学领域:
- 禽类的健康 禽类的健康
- 寄生虫学的寄生虫学
- 免疫学 免疫学 免疫学
背景情况:
- 状菌病对健康和家禽产业构成重大威胁.
- 制定有效的,非抗药性预防策略至关重要.
- 众所周知,ChangQing化合物的治疗潜力是众所周知的,但其预防作用尚未被探索.
研究的目的:
- 评估ChangQing化合物的预防性疗效,以预防的状菌病.
- 评估ChangQing化合物对生存,生长,寄生虫负荷,免疫状态和肠道微生物群的影响.
主要方法:
- 建立一个模型,用于预防状菌病.
- 在暴露前预防 (PrEP) 和暴露后预防 (PEP) 组中,用5.0μg/L的ChangQing化合物.
- 综合分析了生存率,体重增加,卵巢脱落,抗菌性指数 (ACI),免疫参数 (IgA,IgG,IgM),组织病理和细胞微生物多样性.
主要成果:
- 在PrEP (178.10) 和PEP (173.12) 组中,ChangQing化合物显著改善了生存率和抗菌指数 (ACI).
- 观察到减少了病变和增加了Fabricius指数的脏,肝脏和毛囊.
- 高水平的IgA,IgG和IgM,以及增加的有益细菌 (Lactobacillus, Bacteroides, Alistipes) 和减少的病原体 (Escherichia-Shigella).
结论:
- 长青化合物显示出对的状菌病有显著的预防作用.
- 它调节免疫系统,改善肠道微生物平衡.
- 为了解传统中医在家禽中的抗寄生虫机制提供了基础.
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