机体和炎症:对微生物失衡的系统审查和尿路疾病的诊断工具
Sara Palumbo1, Giuseppe Lucarelli2, Francesco Lasorsa2
1Department of Molecular Medicine and Medical Biotechnologies, University of Naples, Naples, Italy; CEINGE Biotecnologie Avanzate-Franco Salvatore S.C.A.R.L., Naples, Italy.
Urology
|April 5, 2025
概括
尿路微生物的不平衡,即尿路微生物的失衡,会导致诸如尿路感染之类的炎症性疾病. 益生菌在恢复平衡和减少复发方面表现有前途.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 尿路微生物组 (urobiome) 在保持尿路健康方面发挥着至关重要的作用.
- 尿管中的失调或失衡越来越多地与炎症性尿路疾病有关.
- 了解这些变化对开发有效治疗至关重要.
研究的目的:
- 综合当前关于尿道炎症疾病中一些改变的知识.
- 审查用于检测多巴基因组失生症的创新诊断进展.
- 探索新兴的治疗策略,以向可可多组异位生物病.
主要方法:
- 科学数据库的系统审查.
- 包括原始的英语语言研究,涉及人类尿样.
- 关键词:微生物组,尿液,第一天早上的样本,第一个空白.
主要成果:
- 20项研究揭示了与大肠杆菌和M. genitalium等病原体相关的细胞组中断,导致炎症.
- 先进的诊断 (元基因组学,元蛋白组学,临床检测) 提高了病原体的检测.
- 益生菌干预 (乳杆菌物种) 证明在减少复发和炎症方面具有有效性.
结论:
- 尿基组失生症是尿路炎症疾病的关键因素.
- 创新的诊断和向治疗,特别是益生菌,具有改善患者结果的巨大潜力.
- 需要进一步的研究来完善和验证这些策略的临床使用.
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