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纳米结构的TPS/PVA/CNC薄膜用于持续的氧化铜纳米颗粒发布:朝着先进的透皮包装系统

Amanda de S M de Freitas¹, Jéssica de S Rodrigues², Sofia Municoy³

¹Polymers and Biopolymers Technology Laboratory (TecPBio), Institute of Science and Technology (ICT), Federal University of São Paulo (UNIFESP), São José do Campos, Brazil; Science and Technology Center for Sustainability (CCTS), Federal University of São Carlos (UFSCar), Sorocaba, Brazil.

International journal of pharmaceutics

|April 5, 2025

概括

用纤维素纳米晶体和氧化铜纳米颗粒增强的可生物降解热塑性粉纳米复合材料薄膜表现出增强的机械强度和抗氧化性能,使它们适用于先进的伤口包裹.

科学领域:

材料科学材料科学材料科学
生物材料工程生物材料工程
纳米技术纳米技术

背景情况:

传统的伤口包往往缺乏生物降解性和先进的功能.
越来越需要创新的生物材料来支持伤口愈合,并且对环境友好.

研究的目的:

开发和描述新的可生物降解纳米复合材料薄膜,用于通过皮肤包装的应用.
研究纤维素纳米晶体 (CNC) 和氧化铜纳米颗粒 (NPCuO) 对薄膜特性的影响.
评估这些纳米复合材料作为先进的伤口带的潜力.

主要方法:

热塑性粉 (T) 纳米复合材料薄膜用聚乙醇 (P) 和使用造技术的CNC不同度准备.
铜氧化物纳米颗粒 (NPCuO) 的合成和特征.
在受控释放研究中,最佳的T/P/CNC薄膜被NPCuO修改为NPCuO.
广泛的表征包括机械测试 (拉力),膨胀能力,接触角度,热重力测量分析 (TGA),里埃变换红外光谱学 (FTIR),水蒸气透性和细胞相容性测试.
使用UV-Vis光谱学评估了NPCuO释放动力学和抗氧化活性.

主要成果:

加入10%的CNC显著提高了片的机械强度 (破裂时的应力增加了三倍).
纳米复合材料薄膜表现出水友性 (接触角度为62°),在PBS中具有良好的溶解性,并且在8小时内控制释放NPCuO.
随着CNC和NPCuO的添加,水蒸气的透性增加,这表明它适合于伤口管理.
经过NPCuO修饰的薄膜在96小时内表现出显著的抗氧化活性,表现优于没有NPCuO的薄膜.
细胞相容性测试证实了开发材料的安全性.

结论:

开发的热塑性粉/聚乙醇/纤维素纳米晶/氧化铜纳米颗粒 (T/P/10CNC/NPCuO) 纳米复合材料具有机械,透性和抗氧化性能的有前途的组合.
这些材料是开发下一代可生物降解的透皮带的合适候选者.
该研究强调了纳米复合材料设计在先进伤口护理解决方案中的潜力.

关键词:

纤维素纳米晶体纤维素纳米晶体铜氧化物纳米粒子铜氧化物纳米粒子持续释放的释放是一种持续释放.热塑性粉的使用方法通过皮肤的带.

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