遵守饮食指南和肝癌风险:来自两个前性队列研究的结果
Jia-Yi Tuo1, Qiu-Ming Shen2, Zhuo-Ying Li2
1State Key Laboratory of Systems Medicine for Cancer & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China; School of Public Health, Shanghai Jiaotong University School of Medicine, Shanghai, PR China.
坚持某些健康的饮食模式,如逆转的实证饮食炎症模式 (rEDIP),可能会降低肝癌风险,特别是在女性中. 需要进一步的研究来证实这些发现,并了解参与饮食和预防肝癌的机制.
科学领域:
- 流行病学 流行病学
- 营养科学 营养科学
- 在瘤学瘤学.
背景情况:
- 对肝癌风险的饮食因素进行了研究,但证据仍然不确.
- 这项研究系统地评估了十个食指南遵守得分与肝癌风险之间的关联.
研究的目的:
- 为了确定与预防肝癌相关的饮食模式.
- 评估遵守特定饮食指南与肝癌风险之间的关系.
主要方法:
- 在城市上海进行了两项前性队列研究 (59,844名男性,72,680名女性,年龄在40-74岁之间).
- 通过食物频率调查问卷评估饮食摄入量;计算准则合规得分.
- 考克斯比例危险回归模型用于分析饮食得分与肝癌风险之间的关联.
主要成果:
- 十条饮食指南与男性肝癌风险之间没有显著的关联.
- 修改后逆转的实证饮食炎症模式 (rEDIP) 显示与女性肝癌风险的反向关联 (HR per SD = 0.94).
- 对rEDIP的不利关联在年轻女性 (<55岁) 中更为强烈. 在男性吸烟者中观察到mDRRD和mWCRF/AICR的显著反向关联.
结论:
- 更多地坚持特定的健康饮食模式 (rEDIP,mDRRD,mWCRF/AICR) 与肝癌风险相反相关.
- 这些关联在特定人群中显得更加明显,例如女性和男性吸烟者.
- 需要进一步的研究来证实这些发现,并探索潜在的机制.
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