失眠,早起和晚起与小海马体积和大白质超强度负担相关
Clémence Cavaillès1, Sylvaine Artero2, Jerome J Maller3
1Institute for Neurosciences of Montpellier INM, University of Montpellier, INSERM, 80 Av. Augustin Fliche, Montpellier, 34295, France.
Alzheimer's research & therapy
|April 5, 2025
概括
睡眠时间和失眠症状与大脑结构变化有关,特别是海马体积减少和白质过强度增加 (WMH). 这些发现表明,睡眠会影响与痴呆风险相关的神经退行性和血管路径.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
- 老年学是一门学科.
背景情况:
- 睡眠障碍与痴呆症风险增加有关,其潜在机制尚不清楚.
- 神经退行性和血管路径与睡眠和痴呆之间的关系有关.
- 研究特定的睡眠特征及其与大脑结构的关联至关重要.
研究的目的:
- 检查临床睡眠特征和多睡眠特征 (PSG) 与海马和白质超强度 (WMH) 体积之间的关系.
- 探索睡眠时间,失眠症状和睡眠结构如何与神经退行和血管大脑变化有关.
- 了解老年人睡眠与大脑结构的联系.
主要方法:
- 在法国ESPRIT队列中对678名65-80岁的参与者进行了横截面研究.
- 使用MRI测量海马和WMH体积.
- 收集了自我报告的睡眠数据,并对参与者的子集进行了门诊多睡眠学 (PSG).
- 采用多变量逻辑回归来分析睡眠变量与大脑体积之间的关联.
主要成果:
- 早 (≤6 am) 和晚 (>8 am) 的起床时间与海马体积较低有关.
- 早起时间和失眠症状与较大的WMH体积相关.
- 晚睡时间 (晚上≥11点) 与较低的WMH体积有关.
- 虽然PSG数据显示了相关性 (例如,较高的REM睡眠百分比与较低的WMH),但在统计纠正后,这些并没有持续下去.
结论:
- 具体的睡眠特征,睡眠时间和大脑结构体积 (海马和WMH) 之间存在明显的关联.
- 这些发现强调了睡眠和睡眠时间在大脑结构中的重要作用.
- 需要进一步的研究来阐明将睡眠障碍与神经退行性和血管变化联系在一起的机制.
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