对COVID-19对儿科大脑影响的多模式MRI分析
Ting Peng1,2, Chaowei Zhang3, Pingping Xie2
1Fujian Key Laboratory of Neonatal Diseases, Children's Hospital of Fudan University (Xiamen Branch), Xiamen Children's Hospital, Xiamen, 361000, China.
Scientific reports
|April 5, 2025
概括
在儿童中,轻度的COVID-19可能会导致大脑变化,包括皮质指标和结构共变网络的改变. 需要进一步的研究,以了解儿科患者的长期神经发育影响.
科学领域:
- 神经科学是一个神经科学.
- 儿科神经学 儿科神经学
- 传染性疾病 传染性疾病
背景情况:
- COVID-19影响中枢神经系统,但对儿科的影响不太了解.
- 成人COVID-19的神经影响已被记录,需要进行儿科研究.
研究的目的:
- 在患有轻度COVID-19的儿童中调查皮质指标和结构共变网络 (SCN).
- 在儿科患者中评估COVID-19后淋巴功能非侵入性MRI代理的变化.
主要方法:
- 在19名患有COVID-19的儿童和22名健康对照者之间比较MRI数据 (皮层指标,LGI,SCNs,淋巴代理).
- 使用高分辨率T1加权和扩散加权MRI.
- 用于皮层分析和SCN网络分析的顶点通用线性模型.
主要成果:
- 患有COVID-19的儿童在左上皮质皮质中表现出皮质区域,体积和局部化指数 (LGI) 的增加.
- 在左侧脑后皮层观察到皮层厚度增加.
- 在COVID-19组中发现了SCN拓的变化和更大的胆脉 (CP) 体积,这表明神经炎症.
结论:
- 轻度的COVID-19可能会导致儿童的可测量的脑部变化.
- 研究结果表明,潜在的病毒诱导的神经炎症会影响儿童大脑结构.
- 进一步调查COVID-19后儿童的长期神经发育结果至关重要.
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