相关实验视频
Updated: May 16, 2025

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Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
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在重症新生儿和儿童中暴露于环松和代谢物
Suneetha Desiraju1, Emily Zhao2, Jordan Kuiper3
1Department of Pediatrics, Division of Neonatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Pediatric research
|April 5, 2025
概括
重症儿童通过静脉注射液体和药物暴露于有毒的环松. 这种化学物质被发现在所有测试的医院溶液中,以及在重症监护中的婴儿和儿童的血液和尿液中.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 儿科 儿科 儿科
背景情况:
- 环松是一种有毒的挥发性有机化合物,用于静脉注射 (IV) 液体施用装置中的溶剂密封剂.
- 危急病患儿童中环合和其代谢物的暴露来源和水平没有得到很好的描述.
研究的目的:
- 确定危急病的婴儿和儿童中环松的暴露来源.
- 在这些脆弱人群中测量环松及其代谢物的血和尿液水平.
主要方法:
- 儿童在儿科重症监护室 (ICU) 的预期招生 (n=66).
- 在早产新生儿中进行的多中心试验的二次分析 (n=69).
- 在医疗液体,血和尿液中对循环赫萨和其代谢物 (转-1,2-循环赫萨二醇,转-1,4-循环赫萨二醇) 的连续测量.
主要成果:
- 在100%的检测到的IV溶液 (液体,药物,透析剂,红细胞袋;n=53) 中检测到环松.
- 在两个队伍中,尿液中的环松和代谢物水平高于血.
- 在新生儿中,血/尿液环松的峰值是在1天;代谢物水平的峰值是在7-14天.
结论:
- 对于需要重症监护的儿童,特别是那些接受静脉注射液体和药物的儿童,对环松的暴露可能是不可避免的.
- 进一步的研究至关重要,以制定减轻新生儿和儿科重症监护室患者对环松暴露的策略.
- 由于其存在于必要的医疗用品中,直接暴露于医院来源的环松的血液中,需要进一步调查.
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