使用抗精神病药物的痴呆症患者住院和死亡率的预测因素和调节因素:系统性审查
Timothy Josh D Tan1, Edward C Y Lau1, Trong H Le1,2
1Faculty of Medicine and Health, The University of Sydney School of Pharmacy, The University of Sydney, Sydney, NSW, 2006, Australia.
Drugs & aging
|April 5, 2025
概括
这项研究确定了使用抗精神病药物的老年痴呆症患者住院和死亡风险增加的因素. 主要风险包括抗精神病类型,高剂量,年龄较大和二二使用.
科学领域:
- 老年医学 老年医学
- 心理药理学 心理药理学
- 痴呆症护理 痴呆症护理 痴呆症护理
背景情况:
- 抗精神病药物可以控制痴呆症 (BPSD) 的行为和心理症状.
- 与痴呆症中抗精神病药物使用相关的不良结果风险增加是一个令人担忧的问题.
- 影响这些不良结果的因素仍未得到充分研究.
研究的目的:
- 确定与住院风险相关的因素.
- 确定与死亡风险相关的因素.
- 在老年痴呆症患者使用抗精神病药物.
主要方法:
- 从2010年到2024年4月,在四个数据库 (Embase,Medline,PsycINFO,Web of Science) 进行系统的文献搜索.
- 包括对老年人 (≥65岁) 痴呆症和可提取风险数据的研究.
- 使用乔安娜·布里格斯研究所工具和叙事合成进行偏见风险评估.
主要成果:
- 抗精神病类型和高剂量与增加的死亡率和住院风险有关.
- 患者的因素,如年龄较大和同时使用二二类药物增加了死亡风险.
- 新抗精神病药物使用和二二类药物使用与更高的住院风险有关.
结论:
- 几种因素显著影响了服用抗精神病药物的痴呆症患者的住院和死亡风险.
- 临床医生在处方时必须仔细考虑这些已识别的风险因素.
- 有信息的处方可以减轻这种脆弱人群的不良结果.
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