伴随性Sjögren病在NMOSD患者中:对神经系统疾病严重程度和复发的影响
Wanqing Wu1, Wenbo Yang1, Bo Deng1
1Department of Neurology, National Center for Neurological Disorders, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, 200040, China.
Arthritis research & therapy
|April 5, 2025
概括
神经omyelitis光学谱系障碍 (NMOSD) 患有斯乔格伦病 (SjD) 的患者表现出更严重的症状和更早的复发. 结合年龄,残疾分数,白细胞计数和特定抗体的预测性诺莫грам可以评估NMOSD中共存SjD的风险.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
背景情况:
- 神经脊髓炎光学谱系障碍 (NMOSD) 是一种影响中枢神经系统的自身免疫性疾病.
- 在NMOSD患者中格伦病 (SjD) 的同时发生可以影响疾病表型和进展.
- 对于理解疾病异质性而言,具有和没有SjD的NMOSD的特征至关重要.
研究的目的:
- 描述NMOSD患者的临床和准临床表型,包括并存SjD的患者和没有SjD的患者.
- 开发和验证用于评估NMOSD患者SjD风险的预测性名谱.
- 确定NMOSD中SjD同时发生的独立预测因子.
主要方法:
- 分析了155名NMOSD患者的队列,他们对AQP4-IgG呈阳性.
- 患者被分为导出 (108) 和验证 (47) 组.
- 后勤回归和名录构造被用来识别预测因素和评估风险.
主要成果:
- 70名患者 (45.16%) 与SjD同时存在.
- 对SjD的独立预测因素包括年龄,扩大残疾状态量表 (EDSS) 评分,白细胞 (WBC) 计数,以及对类风湿因子 (RF),抗SSA (Ro) 和抗SSB (La) 抗体的阳性.
- 诺米图表显示出高的预测准确性 (AUC在导出时为0.95,在验证时为0.91).
- 患有SjD的NMOSD患者更早出现了临床复发,并且更早达到更高的EDSS得分.
结论:
- 患有SjD的NMOSD患者表现出更严重的疾病过程和更早的复发.
- 结合年龄,EDSS,白细胞计数和特定的自身抗体的诺莫图谱可以有效预测NMOSD患者共存SjD的风险.
- 该工具有助于识别患有SjD风险较高的NMOSD患者,促进及时诊断和管理.
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