相关实验视频

Updated: Jul 27, 2026

Zebrafish as a Model to Assess the Teratogenic Potential of Nitrite

Zebrafish as a Model to Assess the Teratogenic Potential of Nitrite

Published on: February 16, 2016

长期暴露于2,4-di-tert-butylphenol会损害斑马鱼的生育能力,并影响后代的发育

Huina Gao¹, Yuchen Wang¹, Xuefang Liang¹

¹Inner Mongolia Key Laboratory of Environmental Pollution Control & Low Carbon Resource Utilization, Ministry of Education Key Laboratory of Ecology and Resource Use of the Mongolian Plateau, School of Ecology and Environment, Inner Mongolia University, Hohhot 010021, China.

Journal of hazardous materials

|April 6, 2025

概括

在斑马鱼中,暴露于2,4-di-tert-butylphenol (2,4-DTBP) 降低了卵子的产量,并延迟了淋巴细胞的成熟. 这种抗氧化剂还导致了代际毒性,影响后代的发育和免疫力.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
内分泌学在内分泌学.

背景情况:

2,4-di-tert-butylphenol (2,4-DTBP) 是一种常见的环境抗氧化剂.
它的内分泌干扰潜力和生殖效应尚未完全理解.

研究的目的:

为了研究2,4-DTBP在成年斑马鱼中的生殖毒性.
探索2,4-DTBP暴露对后代的代际影响.

主要方法:

成年斑马鱼在60天内暴露在5和50nM的2,4-DTBP中.
评估了生殖参数,淋巴体成熟和荷尔蒙水平.
分子对接被用来预测与激素受体的相互作用.
评估了对F1幼虫的代际影响.

主要成果:

暴露于2,4-DTBP减少了斑马鱼的卵子产量和延迟了淋巴体成熟.
生殖功能受损与改变的17β-雌激醇/ (E2/T) 比率和下丘脑-垂体-淋巴结核 (HPG) 轴基因表达有关.
分子对接表明2,4-DTBP与雌激素受体和芳香酶 (CYP19) 相结合.
父母暴露导致F1幼虫的代际毒性,影响了发育和免疫力.

结论:

2,4-DTBP在斑马鱼中表现出生殖毒性.
它破坏了内分泌系统,并可能导致代际影响.
这些发现有助于对2,4-DTBP的生态风险评估.

关键词:

发展性毒性发展性毒性代际转移是代际转移.类抗氧化剂是一种性抗氧化剂.生殖功能障碍发生生殖功能障碍类固醇激素合成的合成

更多相关视频

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

Studying Neurobehavioral Effects of Environmental Pollutants on Zebrafish Larvae

Studying Neurobehavioral Effects of Environmental Pollutants on Zebrafish Larvae

Published on: February 5, 2020

相关概念视频

Toxicity Testing in Animals

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...