血代谢学区分和预测冠状动脉疾病患者的预后,具有不同的营养状况

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Chengyang Lai¹, Yangchen Li¹, Wenwei Luo²

¹School of Medicine, South China University of Technology, Guangzhou, Guangdong, China; Department of Pharmacy, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.

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|April 6, 2025

概括

冠状动脉疾病 (CAD) 患者的营养不良与更糟糕的结果有关. 特定的血液代谢物,如升高的β-pseudouridine和dulcitol,调解这种风险,建议针对性的营养干预措施,以改善CAD预后.

科学领域:

心血管医学心血管医学
代谢学代谢学代谢学
营养科学营养科学

背景情况:

营养不良是冠状动脉疾病 (CAD) 患者的一个重大问题.
连接营养状况与不良心血管结果的代谢基础仍然不完全理解.
识别特定的代谢物可能会阐明连接营养不良和CAD的不良预后的机制.

研究的目的:

研究与营养不良相关的代谢机制及其对CAD患者预后的影响.
为了确定特定的代谢物,调解营养状况和不良心血管事件之间的关系.
评估针对代谢物向的营养干预措施在治疗CAD中的潜力.

主要方法:

用三种查工具评估了5182名CAD患者的营养状况.
使用统计分析,包括限制立方线和考克斯回归来评估结果.
多重线性回归,中介分析和最小绝对收缩和选择运算符 (LASSO) 用于识别和整合关键代谢物.

主要成果:

营养状况不佳与所有原因死亡率增加和主要不良心血管事件 (MACE) 显著相关.
增加的β-伪尤里丁和dulcitol,以及降低的l-三和LPC (18:2/0:0) 被确定为关键的介导代谢物.
将这些代谢物与临床变量相结合,提高了CAD患者不良结果的预测准确度.

结论:

根据营养状况,CAD患者的新陈代谢概况显著不同.
特定的营养相关代谢物在调解营养不良和CAD不良预后之间的联系方面发挥着至关重要的作用.
针对已识别的代谢物进行的有针对性的营养干预可以提供一种新的策略,以改善CAD的结果.

关键词:

冠状动脉疾病是一种冠状动脉疾病.营养不良营养不良调解分析调解分析代谢学代谢学代谢学营养状态营养状况

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