在 thalamus 前核刺激后,普遍性的长期发作减少

在 thalamus 前核刺激后,普遍性的长期发作减少

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Zachary L Bernstein¹, Ashley Lb Raghu², Amir P Divanbeighi Zand³

¹Department of Neurosurgery, Emory University, Atlanta, GA, USA.

Epilepsy & behavior : E&B

|April 6, 2025

概括

在其他治疗方法失败时,thalamus前核深脑刺激 (ANT DBS) 对泛性 (GE) 是有前途的. 一个案例研究和文献综述表明,ANT DBS可以减少或消除GE患者的泛性强力克隆性发作.

科学领域:

神经学神经学
神经外科神经外科
发病学 (Epileptology) 是一个专业的学科.

背景情况:

胸部前核 (ANT) 深度大脑刺激 (DBS) 是FDA批准用于焦点.
在最初的试验中没有评估泛性 (GE),但在受试者中减少了双边强力-克隆性的焦点.
在罕见的情况下,ANT DBS已被用于GE患者.

研究的目的:

报告一个成功的ANT DBS病例,一个患有异常性GE的患者.
系统地审查关于在GE患者中使用ANT DBS的文献.
评估ANT DBS在GE中的有效性和情况.

主要方法:

一个27岁的男性病例报告,患有异常性GE耐药性和VNS.
对用ANT DBS治疗的GE患者进行PubMed,Cochrane和Google Scholar的系统文献审查.
总结了13篇涉及23名GE患者的出版物中的临床发现,特征和结果.

主要成果:

患者在ANT DBS后的五年内没有发生泛性强度-克隆性 (GTCS),其他也减少了.
系统性审查确定了23名GE患者接受了ANT DBS治疗,通常是在VNS失败后.
在报告结果的13名患者中,有3名患者变得没有GTCS,这表明ANT DBS的有效性.

结论:

在ANT节点的高频刺激可以调节GE网络.
在既有疗法失败时,ANT DBS是GE的潜在治疗选择.
需要进一步的结构化研究来验证ANT DBS对一般性的有效性.

关键词:

泰拉木斯前核的前核.深度大脑刺激是什么?电刺激是一种电气刺激.是一种病.的手术手术是在.泰拉姆斯 (thalamus) 是一个神经元.

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