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血清微量元素与克罗恩病患者临床特征和肠道微生物群的相关性
Yuanyuan Wang1, Yumei Lin2, Jiaxing Feng2
1Department of Gastroenterology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361004, China; Department of Gastroenterology, Jingjiang People's Hospital Affiliated to Yangzhou University, Taizhou 214500, China.
在中国克罗恩病中观察到微量元素的变化,包括铜的增加和的减少.
科学领域:
- 胃肠病学和营养科学 胃肠病学和营养科学
- 微生物组研究 微生物组研究
背景情况:
- 克罗恩氏病 (CD) 的发病与肠道微生物群失衡和改变的微量元素水平有关.
- 了解CD患者的微量元素状况对于管理疾病至关重要.
研究的目的:
- 为了研究中国CD患者的微量元素变化 (,铜,,).
- 探索微量元素状态,临床特征和肠道微生物群之间的相关性.
主要方法:
- 诱导合血质谱仪用于血清微量元素分析.
- 评估营养状况 (BMI,白蛋白) 和疾病严重程度 (CDAI,CRP).
- 16S rRNA基因测序用于便肠道微生物群分析.
主要成果:
- 与对照组相比,CD患者的血清铜含量增加,血清含量减少.
- 和水平与营养状况正相关.
- 和铜水平与疾病严重程度有关.
- 缺乏与改变肠道微生物群的多样性和丰富性有关.
结论:
- 中国CD患者的血清微量元素水平发生变化,与营养状况和疾病严重程度有关.
- 在CD中缺乏与肠道微生物群的变化有关,这表明存在复杂的相互作用.
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