在患有肠道微生物过度生长的患者中,独家可口的基本饮食的效果,耐受性和安全性
Ali Rezaie1, Bianca W Chang2, Juliana de Freitas Germano3
1Medically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California; Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai, Los Angeles, California.
概括
一种可口的元素饮食 (PED) 有效地改变了肠道微生物组,并改善了细肠细菌过度生长 (SIBO) 和肠道甲素过度生长 (IMO) 的患者的症状. 新型饮食表现出良好的耐受性和安全性,呼吸测试正常化和症状缓解显著.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究的研究.
- 饮食干预措施 饮食干预措施
背景情况:
- 元素饮食 (EDs) 调节肠道微生物群,但患有不良的味道,阻碍了坚持.
- EDs对微生物驱动的疾病,如小肠细菌过度生长 (SIBO) 和肠子甲素过度生长 (IMO) 的影响仍未得到充分研究.
- 开发了一种新的可口元素饮食 (PED),以解决坚持问题的问题.
研究的目的:
- 评估一种新的可口性ED (PED) 的效果,耐受性和安全性.
- 评估PED对SIBO和/或IMO患者肠道微生物组合的影响.
- 确定这些患者群体对PED的症状和生理反应.
主要方法:
- 招募了SIBO和/或IMO阳性乳糖呼吸测试的成年受试者.
- 参与者接受了为期2周的独家口服PED干预,随后进行了为期2周的饮食重新引入阶段.
- 主要终点:便微生物组的变化. 二级终点:耐受性,呼吸测试正常化,便形式,症状和不良事件.
主要成果:
- 所有30名受试者都能耐受PED,表现出更好的粘附性与增强的口感.
- 观察到肠道微生物组合的显著变化,包括某些细菌的数量减少和Methanobrevibacter smithii的减少.
- 在呼吸测试中,PED导致甲和水平显著降低 (73%的正常化),显著缓解症状 (83%的全球缓解),并且没有严重的不良事件.
结论:
- 可口味的元素饮食 (PED) 显著影响SIBO/IMO患者的肠道微生物群.
- 增强的味觉性提高了对元素饮食的耐受性和坚持.
- 需要进行更长的随访时间的大型研究,以证实对PED反应的持久性.
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