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MAFLD/MASLD和亚型与心血管疾病结局的比较关联

Huizhen Jin¹, Zhuoshuai Liang¹, Xinmeng Hu¹

¹Department of Epidemiology and Biostatistics, School of Public Health of Jilin University, Changchun, 130021, China.

Nutrition, metabolism, and cardiovascular diseases : NMCD

|April 6, 2025

概括

与代谢功能障碍相关的脂肪肝病 (MAFLD) 和与代谢功能障碍相关的脂肪性肝病 (MASLD) 会增加心血管疾病 (CVD) 的风险. 代谢健康和酒精消费是评估这些风险的关键因素,比肥胖更重要.

科学领域:

肝病学肝病学是一种肝病学.
心脏病学心脏病学
代谢疾病代谢疾病

背景情况:

与代谢功能障碍相关的脂肪性肝病 (MASLD) 是作为代谢功能障碍相关的脂肪性肝病 (MAFLD) 的替代方案.
了解这些肝病与心血管结果之间的关系对于患者管理至关重要.

研究的目的:

调查影响MAFLD和MASLD与主要心血管结果之间的关联的因素.
确定代谢健康,肥胖和酒精消费在预测这些肝病患者心血管疾病 (CVD) 风险方面的相对重要性.

主要方法:

分析了来自340,998名参与者的英国生物库数据.
利用多变量Cox比例危险模型来评估MAFLD和MASLD对心血管疾病发病率的影响.
随访参与者的中位数为13.5年,记录了主要的心血管事件.

主要成果:

无论是MAFLD (HR=1.52) 还是MASLD (HR=1.42) 都与心血管疾病风险的增加有显著关联.
糖尿病的MAFLD (HR=2.26) 和与酒精有关的肝病 (ALD) (HR=1.65) 显示出最高的心血管疾病风险.
在超重个体中没有代谢功能障碍的MAFLD与心血管疾病风险增加无关.

结论:

代谢健康状况和酒精消耗是MAFLD/MASLD患者心血管疾病结果的更重要的预测因素,而不是肥胖.
这些发现强调了代谢和生活方式因素在脂肪肝患者心血管风险分层中的重要性.

关键词:

心血管疾病的心血管疾病.与代谢功能障碍相关的脂肪肝疾病.与代谢功能障碍相关的脂肪性肝病.脂肪性肝病是什么? 脂肪性肝病是什么?英国生物银行

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