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16. 一十六. 一十六. 一十六. 慢性胰腺炎的疼痛 慢性胰腺炎的疼痛
Laura van Zeggeren1, Raha Boelens Nabbi2, Jan Willem Kallewaard3,4
1Department of Anesthesiology and Pain Medicine, Rijnstate Hospital, Arnhem, The Netherlands.
概括
管理慢性胰腺炎的疼痛是复杂的,需要个性化的方法. 有效的策略整合了医疗,生活方式和心理干预,由于临床试验有限,通常以专家意见为指导.
科学领域:
- 胃肠病学 胃肠病学
- 疼痛医学 医学 疼痛医学
- 胰腺学 胰腺学
背景情况:
- 慢性胰腺炎涉及复发性炎症,导致纤维组织的替代.
- 慢性胰腺炎的疼痛具有复杂的感觉,感觉和神经病的组成部分.
- 中央和外周敏感性,神经可塑性和神经性炎症有助于疼痛.
研究的目的:
- 审查和总结慢性胰腺炎疼痛的诊断和治疗.
- 为提供慢性胰腺炎疼痛的当前管理策略的概述.
主要方法:
- 关于诊断和治疗慢性胰腺炎的文献综述.
- 综合观察研究和专家意见的发现.
主要成果:
- 治疗是通过成像指导的,阻塞性疾病是通过内镜/手术管理的,而非阻塞性疾病是通过医学管理的.
- 止痛药的范围从非阿片类药物到阿片类药物,辅助剂和生活方式的改变至关重要.
- 干预选择,如射频除和脊髓刺激缺乏可靠的试验数据,但可能提供阿片类药物节约效应.
结论:
- 慢性胰腺炎的疼痛管理需要一个多维的,个性化的策略.
- 由于缺乏随机试验,治疗决策通常依赖于专家的共识.
- 整合药理学,非药理学和多学科方法是有效控制疼痛的关键.
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Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
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