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随着时间的推移,化的生物分布和诱导的MRI对比度在小鼠器官中

Keyu Zhuang^1,2, Kyle D W Vollett^1,2, Minbo Hou^3,4

¹Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.

Magnetic resonance in medicine

|April 7, 2025

概括

皮下注射的化 (MnCl2) 在小鼠中优化了增强型MRI (MEMRI) 的对比度. 量身定制剂量和时间是器官特异性T1增强而无毒性的关键.

科学领域:

生物医学成像技术生物医学成像技术
药理动力学药理动力学
毒理学毒理学毒理学

背景情况:

增强型MRI (MEMRI) 使用化 (MnCl2) 进行增强型T1加权成像.
优化MnCl2的输送和生物分布对于有效的MEMRI和避免毒性至关重要.
了解不同器官的MnCl2吸收和对比度增强的时间过程至关重要.

研究的目的:

在小鼠体内进行皮下注射的MnCl2的生物分布.
通过表征MnCl2诱导的T1对比度增强来优化MEMRI.
为了确定特定器官的最佳注射剂量和成像间隔,同时避免血液峰.

主要方法:

在小鼠中研究了0.2和0.4mmol/kg剂量的Mn生物分布和T1对比度,注射后2,6和24小时.
在3T时利用T1加权的MRI和T1映射.
使用ICP-AES量化心脏,肝脏,脏,肌肉,肺部,脏和血液中的量化含量;通过组织学评估器官毒性.

主要成果:

0.2 mmol/kg的剂量在心脏,肝脏和脏产生了显著的T1增强,在2小时内达到峰值.
骨肌肉需要0.4 mmol/kg才能在24小时内达到峰值增强.
在脏,肺和血液中的度峰值发生在2小时后;在测试剂量下没有观察到器官毒性.

结论:

皮下MnCl2注射在研究的组织中提供了显著的T1对比度增强.
在0.4mmol/kg的最大测试剂量下没有观察到任何毒性.
最佳的MEMRI需要根据目标器官量身定制注射剂量和注射后成像时间.

关键词:

心灵的心灵心灵的心灵心灵的心灵脏脏脏脏肝脏肝脏肝脏肝脏肝脏肝脏的生物分布的生物分布这是骨肌肉的骨架肌肉.毒性的毒性毒性的毒性

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