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Updated: May 17, 2025

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解决因多基因风险评分中的样本重叠导致的过度拟合偏差

Seokho Jeong1,2, Manu Shivakumar2, Sang-Hyuk Jung2,3

  • 1Graduate School of Data Science, Seoul National University, Seoul, Republic of Korea.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|April 7, 2025
PubMed
概括

在阿尔茨海默病 (AD) 研究中的样本重叠使多基因风险得分 (PRS) 膨胀. 我们开发了重叠调整的PRS (OA-PRS) 来纠正这种偏差,确保更准确的PRS估计,并防止在AD遗传研究中过度匹配.

关键词:
阿尔茨海默病的疾病阿尔茨海默病的疾病.遗传风险因素是遗传风险因素.多基因风险得分的多基因风险得分.精准医学是一门精准医学.样品重叠的情况.

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