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Updated: May 17, 2025

Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples
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Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples

Published on: July 29, 2017

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人类疹病毒与头状细胞癌之间的关联:从分子角度来看

Merve Gürler1, Mustafa Kürsat Gōkcan2, Seher Yüksel3

  • 1From the Department of Medical Microbiology, Ankara University Faculty of Medicine, Ankara, Turkey.

Annals of Saudi medicine
|April 7, 2025
PubMed
概括

在头部和部状细胞癌 (HN-SCC) 的发展中研究了疹病毒. 低病毒基因组检测表明,其他因素在HN-SCC病变发生过程中更为突出.

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
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