暴露于高孕期BMI的儿童的性别特异性白质变化
Samson Nivins1, Jess Reynolds2, Gerald F Giesbrecht3
1Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Obesity (Silver Spring, Md.)
|April 7, 2025
概括
孕妇高孕期BMI与儿童白质微观结构的改变有关,影响认知表现. 这些大脑变化显示出性别特异性差异,并强调了母亲体重管理的重要性.
科学领域:
- 神经科学是一个神经科学.
- 发育生物学 发展生物学
- 公共卫生 公共卫生
背景情况:
- 高孕期体重指数 (BMI) 是一个日益严重的公共卫生问题.
- 母胎孕期BMI可能会影响胎儿发育和长期儿童健康结果.
- 了解孕期BMI对早期大脑发育的影响至关重要.
研究的目的:
- 为了研究高孕期BMI (≥25 kg/m2) 和幼儿早期白质微观结构之间的关联.
- 探索母亲妊娠期BMI对儿童大脑发育的潜在性别特异性影响.
- 为了检查改变白质微观结构是否与儿童的认知表现有关.
主要方法:
- 扩散张力成像 (DTI) 用于评估90名2至7岁儿童的白质微观结构 (平均分数异构和平均扩散性).
- 怀孕期的BMI是根据自我报告的体重和测量的身高来确定的.
- 儿童的认知结果使用韦克斯勒学前和初级智力量表进行了评估.
主要成果:
- 暴露于高孕期BMI的儿童在关键的白质道中表现出较低的微分异性质 (FA),包括上端纵向和体.
- 这些FA变化与暴露儿童的认知结果较差有关.
- 观察到性别特异性差异:暴露的男性在骨中显示出更高的FA,而暴露的女性在体中显示出更低的FA.
结论:
- 高孕期BMI与童年早期白质微观结构的显著改变有关.
- 这些大脑变化以性别特定的方式表现出来.
- 在怀孕前和怀孕期间促进健康的生活方式和体重管理对于儿童神经发育的最佳发展至关重要.
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