寻找与全球出生体重和BMI差异相关的环境因素
Per M Jensen1, Marten Sørensen1
1Department of Plant and Environmental Sciences, University of Copenhagen, Frederiksberg, Denmark.
概括
每日温度波动与胎儿生长率和成人肥胖症有关. 这些发现扩大了"成年人疾病的胎儿起源假设",强调了干旱和粮食短缺等环境因素.
科学领域:
- 环境健康 环境健康
- 发育生物学是发展生物学.
- 流行病学 流行病学
背景情况:
- "成年人疾病的胎儿起源假设"假设子宫内生长限制 (IUGR) 影响长期健康.
- 并非所有IUGR的原因都会影响发育轨迹;慢性或季节性IUGR可能影响最小.
- 替代机制,如重复的代谢途径刺激,可能会影响发育轨迹.
研究的目的:
- 调查每日温度变化与胎儿生长率之间的关联.
- 在成人疾病的胎儿起源假设的背景下,探索每日温度幅度和身体质量指数 (BMI) 之间的联系.
- 确定温度振幅等环境因素是否影响胎儿生长率和BMI.
主要方法:
- 评估了每日温度幅度与原始胎儿生长率 (CFGR) 和BMI的全球记录之间的关联.
- 利用来自70个国家的配对出生体重 (BW) 和妊娠年龄 (GA) 数据进行CFGR分析.
- 分析了CFGR与每日温度幅度,季节性温度幅度,年平均温度,卡路里摄入量,BMI,身高和社会经济条件相关.
主要成果:
- 在每日温度幅度和CFGR和BMI之间发现了明确的关联.
- 在每日温度幅度和妊娠年龄,卡路里摄入量或身高之间没有明显的关联.
- 这些发现表明,环境对胎儿生长和随后的BMI有直接的影响.
结论:
- 每日温度幅度与CFGR和BMI有显著的关联.
- 这些结果扩大了对成人疾病胎儿起源假设的生态理解.
- 环境干旱和粮食稀缺,以每日温度幅度表示,可能会影响与胎儿发育有关的疾病的流行.
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