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Updated: May 15, 2025

A Simple Red Blood Cell Lysis Method for the Establishment of B Lymphoblastoid Cell Lines
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淋巴细胞和Jurkat细胞系是开发CRISPR-Cas9方法的有用替代品,以纠正白细胞粘附缺陷基因组缺陷

Ahmad R Ramadan1,2, Noureddine Ben Khalaf3, Khaled Trabelsi4

  • 1Laboratory of Transmission, Control and Immunobiology of Infections (LR16IPT02), Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, Tunisia.

Frontiers in bioengineering and biotechnology
|April 7, 2025
PubMed
概括

通过CRISPR-Cas9基因编辑,在白细胞粘附性缺陷1型 (LAD1) 患者细胞中成功恢复了CD18的表达. 这种精确的校正通过使免疫功能稳定,为LAD1提供了潜在的治疗方法.

关键词:
克里斯普尔-Cas9是什么意思在这里,GNA GRNA GRNA.这就是HDR HDR.这就是ITGB2基因.尤尔卡特细胞系的细胞系白细胞粘附性缺陷第一类 (LAD1)

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