Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Viral Recombination00:57

Viral Recombination

23.1K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.1K
Viral Mutations00:36

Viral Mutations

32.1K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
32.1K
Leaky Scanning02:28

Leaky Scanning

5.0K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

High-affinity optimization potential of the virus neutralizing antibody with twin cysteine-stabilized complementarity-determining region 3.

Frontiers in cellular and infection microbiology·2026
Same author

Postoperative Adjuvant Transcatheterarterial Chemoembolization Should Be Considered Selectively for Patients with Cytokeratin-19 Positive Hepatocellular Carcinoma.

Journal of hepatocellular carcinoma·2025
Same author

Dinucleotide composition representation -based deep learning to predict scoliosis-associated Fibrillin-1 genotypes.

Frontiers in genetics·2024
Same author

Screening for anti-influenza virus compounds from traditional Mongolian medicine by GFP-based reporter virus.

Frontiers in cellular and infection microbiology·2024
Same author

Comprehensive Proteomics Analysis Reveals Dynamic Phenotypes of Tumor-Associated Macrophages and Their Precursor Cells in Tumor Progression.

Journal of proteome research·2024
Same author

Receptor-interacting protein kinase 2 is associated with tumor immune infiltration, immunotherapy-related biomarkers, and affects gastric cancer cells growth <i>in vivo</i>.

Journal of Cancer·2024

相关实验视频

Updated: May 15, 2025

Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies
07:55

Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies

Published on: August 29, 2017

11.6K

基于区间约束的机器学习方法来预测人类适应性流感A病毒的重新分类.

Dan-Dan Zeng1,2, Yu-Rong Cai2, Sen Zhang2

  • 1College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China.

Frontiers in microbiology
|April 7, 2025
PubMed
概括

这项研究揭示了人类适应的甲型流感病毒 (IAV) 中独特的基因组核酸组成,从而能够通过机器学习预测病毒重新分类. 了解这些遗传特征是预测IAV进化和适应的关键.

关键词:
这是H1N1流感.流感A型病毒 (IAV) 的存在.机器学习是机器学习.核酸组成 核酸组成进行重新分类,重新分类.

更多相关视频

Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses
09:07

Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses

Published on: January 20, 2017

9.8K
Generation of Recombinant Influenza Virus from Plasmid DNA
11:31

Generation of Recombinant Influenza Virus from Plasmid DNA

Published on: August 3, 2010

30.3K

相关实验视频

Last Updated: May 15, 2025

Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies
07:55

Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies

Published on: August 29, 2017

11.6K
Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses
09:07

Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses

Published on: January 20, 2017

9.8K
Generation of Recombinant Influenza Virus from Plasmid DNA
11:31

Generation of Recombinant Influenza Virus from Plasmid DNA

Published on: August 3, 2010

30.3K

科学领域:

  • 病毒学 病毒学
  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.

背景情况:

  • 导致A型流感病毒 (IAV) 跨细分重组的机制尚不清楚.
  • 了解病毒遗传兼容性对于预测IAV适应和演变至关重要.

研究的目的:

  • 在IAV中分析病毒核酸组成 (NC) 和跨细分NC相关性.
  • 开发基于NC特征的机器学习 (ML) 模型来预测IAV重组和人类适应.

主要方法:

  • 使用无监督的ML方法来区分适应人类和动物感染的IAV之间的NC.
  • 监督的ML模型,包括随机森林分类器 (RFC) 和多层感知器 (MLP),被开发用于预测人类的适应.
  • 分析包括病毒段中的核酸频率 (T,C,A,G) 和GC/AT含量.

主要成果:

  • 在哺乳动物和鸟类IAV之间的特定IAV段 (PB2,PB1,PA,NP,M1,NS1) 中观察到明显的NC模式.
  • 确定了跨细分NC相关性,其中RNPplus NC与EPplus (HA,NA,M1) NC负相关.
  • 适应人类的NC配置文件准确地区分了人类IAV和鸟类IAV,模拟的IAV显示出高的适应潜力.

结论:

  • 在人类和禽类IAV之间存在着一个独特的,人类适应特异的基因组NC.
  • 跨细分NC相关性对病毒细分重新分类施加约束.
  • 这项研究引入了一种基于ML的新策略,用于使用病毒遗传兼容性来预测IAV重组.