FACdb:农场动物基因,肠道微生物群和代谢物的综合资源
Ze Zhang1,2, Yang Li1, Di Zhang1
1Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China.
Frontiers in microbiology
|April 7, 2025
概括
农场动物连接组数据库 (FACdb) 绘制了牲畜中的基因表达,肠道微生物群和代谢物相互作用. 该资源有助于理解动物生物学,并改善动物福利和产品.
科学领域:
- 农业科学 农业科学
- 生物信息学是一种生物信息学.
- 动物科学动物科学
背景情况:
- 农场动物对经济,社会和文化部门至关重要,影响人类福利.
- 关于宿主-微生物-代谢物相互作用的现有数据库有限,主要集中在人类和小鼠模型上.
- 需要专门为农场动物提供全面的资源.
研究的目的:
- 开发一个全面的数据库 (FACdb) 用于农场动物连接组数据.
- 绘制基因表达,肠道微生物群和农场动物中的代谢物之间的关联网络.
- 为探索这些复杂的生物相互作用提供一个用户友好的平台.
主要方法:
- 使用六个相关性和距离指标 (皮尔森,斯皮尔曼,Cosine,Euclidean,Bray-Curtis,Mahalanobis) 计算了关联.
- 关于基因,肠道微生物群和代谢物的综合数据.
- 开发了一个带有浏览,搜索和交互式可视化工具的界面.
主要成果:
- FACdb包含超过5500万种潜在的相互作用,涉及73571个基因,11046种肠道微生物和4540种代谢物.
- 该数据库提供了一个可访问的平台,用于查询复杂的生物网络.
- 交互式可视化可促进对基因-微生物群-代谢物关系的探索.
结论:
- FACdb是了解农场动物生物学和宿主-微生物-代谢物相互作用的宝贵资源.
- 该数据库支持动物福利的进步和动物产品中微生物资源的利用.
- 由于人类和一些农场动物之间的生理相似性,研究结果可能会为人类健康提供适用于人类健康的见解.
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